|Application ||WB, IHC-P, E|
|Clone Names||betaC clone 1|
|Calculated MW||38238 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Synthetic peptide sequence VPTARRPLSLLYYDRDSNIVKTDIPDMVVEAC corresponding to amino acids 82-113 of mature human activin BetaC-subunit.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Inhibin beta C chain, Activin beta-C chain, INHBC|
|Target/Specificity||Mouse anti-Human Activin betaC-subunit antibody, clone betaC clone 1 recognizes the BetaC-subunit of Activin (BetaC-activin), a member of the transforming growth factor beta (TGF-beta) superfamily and one of a group of proteins which regulate growth and differentiation in a range of cells and tissues, via both autocrine and paracrine pathways. Activins were originally characterised by the formation of specific homo- and heterodimers of activin BetaA- or BetaB-subunits, but additional subunits of activin have since been identified including BetaC, BetaD and BetaE. BetaC-activin, expressed in the liver, prostrate, ovary and testis, has been shown to exhibit both growth promoting and inhibitory properties, and evidence suggests that BetaC-activin can form BetaC homodimers and also heterodimers with BetaA (putative activin AC) and BetaB (putative activin BC). Clone betaC clone 1 has been shown to recognize both monomeric and dimeric BetaC-activin and does not cross react with BetaAf, BetaB or BetaE.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Activin betac-Subunit Antibody, clone betaC clone 1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Mellor, S.L. et al. (2000) Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in human prostate and evidence for formation of new activin heterodimers of beta(C)-subunit.J. Clin. Endocrinol. Metab. 85: 4851-4858. 2. Mellor, S.L. et al. (2003) Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate.Endocrinology. 144: 4410-4419. 3. Gold, E.J. et al. (2005) BetaA- and BetaC-activin, follistatin, activin receptor mRNA and BetaC-activin peptide expression during rat liver regeneration. J. Mol. Endocrinol. 34: 505-515.
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