|Application ||IHC-F, FC|
|Calculated MW||32834 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||BTLA - transfected L cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, CD272, BTLA|
|Target/Specificity||Mouse anti-Human CD272 antibody, clone MIH26 detects human CD272, also known as B- and T-lymphocyte attenuator (BTLA). CD272 is a type I transmembrane glycoprotein which is structurally and functionally related to cytotoxic T lymphocyte antigen-4 (CTLA-4), and programmed death-1 (PD-1). CD272 is a T-cell inhibitory receptor that regulates T cell activation through its interaction with herpes virus entry mediator (HVEM), a co-stimulator receptor of the TNFR family. CD272 may negatively regulate T-cell dependent autoimmune reaction, and polymorphisms in its gene have been associated with Rheumatoid Arthritis.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD272 Antibody, clone MIH26 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Otsuki, N. et al. (2006) Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells.Biochem Biophys Res Commun. 344 (4): 1121-7. 2. Lin, S.C. et al. (2006) Association of a BTLA gene polymorphism with the risk of rheumatoid arthritis.J Biomed Sci. 13 (6): 853-60.1. Zeng, C. et al. (2005) BTLA, a new inhibitory B7 family receptor with a TNFR family ligand.Cell Mol Immunol. 2 (6): 427-32.
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