|Application ||IHC-F, FC|
|Calculated MW||32834 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||BTLA - transfected L cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, CD272, BTLA|
|Target/Specificity||Mouse anti-Human CD272 antibody, clone MIH26 detects human CD272, also known as B- and T-lymphocyte attenuator (BTLA). CD272 is a type I transmembrane glycoprotein which is structurally and functionally related to cytotoxic T lymphocyte antigen-4 (CTLA-4), and programmed death-1 (PD-1). CD272 is a T-cell inhibitory receptor that regulates T cell activation through its interaction with herpes virus entry mediator (HVEM), a co-stimulator receptor of the TNFR family. CD272 may negatively regulate T-cell dependent autoimmune reaction, and polymorphisms in its gene have been associated with Rheumatoid Arthritis.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD272 Antibody, clone MIH26 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
1. Otsuki, N. et al. (2006) Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells.Biochem Biophys Res Commun. 344 (4): 1121-7. 2. Lin, S.C. et al. (2006) Association of a BTLA gene polymorphism with the risk of rheumatoid arthritis.J Biomed Sci. 13 (6): 853-60.1. Zeng, C. et al. (2005) BTLA, a new inhibitory B7 family receptor with a TNFR family ligand.Cell Mol Immunol. 2 (6): 427-32.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.