|Calculated MW||58337 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Thymic epithelial cells from mouse|
|Shelf Life||18 months from date of despatch.|
|Other Names||4F2 cell-surface antigen heavy chain, 4F2hc, Solute carrier family 3 member 2, CD98, Slc3a2, Mdu1|
|Target/Specificity||Rat anti-Mouse CD98 antibody, clone H202-522.214.171.124 recognizes murine CD98, also known as 4F2 and SLC3A2. CD98 is a type II transmembrane glycoprotein which associates with members of the L-type amino transporter family to form a heterodimeric complex.CD98 constitutes the heavy chain of the complex and is required for the surface expression and basolateral localization of the amino acid transporter complex in polarized epithelial cells. The CD98 heavy chain also interacts with beta 1 integrins and regulates their activation through the cytoplasmic domains and transmembrane regions. Studies suggest that overexpression of CD98 may contribute to cell growth and survival by regulating integrin signalling, and therefore may play an important role in tumorigenesis.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD98 Antibody, clone H202-5126.96.36.199 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Kang, Y.S. et al. (2009) Clathrin-independent internalization of normal cellular prion protein in neuroblastoma cells is associated with the Arf6 pathway.J Cell Sci. 122: 4062-9.
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