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Anti-Human CD140a Antibody, clone 35248 (57/20)

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16234
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 35248 (57/20)
Calculated MW 122670 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Purified recombinant human platelet-derived growth factor (PDGF) receptor alpha (extracellular domain), derived from the insect cell line Sf21.
Shelf Life 18 months from date of despatch.
Gene ID 5156
Other Names Platelet-derived growth factor receptor alpha, PDGF-R-alpha, PDGFR-alpha,, Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a antigen, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor 2, PDGFR-2, CD140a, PDGFRA, PDGFR2, RHEPDGFRA
Target/Specificity Mouse anti-Human CD140a antibody, clone 35248 recognizes the human platelet-derived growth factor receptor alpha, a 1089 amino acid, ~180 kDa single pass type I transmembrane glycoprotein.PDGF is a major serum mitogen that can exist as a homo- or heterodimeric protein consisting of disulphide-linked PDGF-A and PDGF-B chains (Hartet al.1990). The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Whereas PDGF receptor alpha binds all three isoforms with high affinity, PDGF R beta binds PDGF-BB and AB but not PDGF-AA (Hartet al.1988). Both PDGF receptor alpha and beta are members of the class III subfamily of receptor tyrosine kinases (Westermark 1995).Mouse anti-Human CD140a antibody, clone 35248 has been reported for use in functional studies. The ND50 was determined as 0.2-0.6 µg/ml for blocking 10 ng/ml of PDGF-AA biological activity on a quiescent confluent cell culture of human WS1 cells.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD140a Antibody, clone 35248 (57/20) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. De Paula, M.L. et al. (2014) The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF-1 signaling in rat and human oligodendrocyte progenitors.
Glia. 62 (1): 64-77. 2. Preisner, A. et al. (2015) Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination.
Acta Neuropathol. 130 (2): 247-61.

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Cat# ABD10197
(40 western blots)
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