Anti-Folate Binding Protein Antibody, clone SF55 (BGN/1210/55)
Mouse Anti-Bovine Monoclonal Antibody
|Clone Names||SF55 (BGN/1210/55)|
|Calculated MW||27922 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Folate binding protein from bovine milk.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Folate receptor alpha, FR-alpha, Folate receptor 1, Folate-binding protein 1, FBP, Milk folate-binding protein, FOLR1|
|Target/Specificity||Mouse anti-folate binding protein antibody, clone SF55, recognizes the folate receptor alpha, also known as folate binding protein (FBP) and Milk folate-binding protein. Folate receptor alpha is a 241 amino acid 30 kDa protein with a 19 amino acid signal peptide and a 7 amino acid c-terminal propeptide cleaved in the mature form. The folate receptor alpha has a high affinity for folate and several reduced folic acid derivatives and mediates the intracelullar delivery of 5 methyltetrahydrofolate. Membrane bound and soluble forms of a high affinity FBP have been found in kidney, placenta, serum, milk, and several cell lines.Mouse anti-folate binding protein antibody, clone SF55 can enhance STAT3 activation through binding to the folatereceptor alpha (Hansenet al.2015).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Folate Binding Protein Antibody, clone SF55 (BGN/1210/55) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Hansen, M.F. et al. (2015) Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha.Cell Signal. 27 (7): 1356-68.1. Henderson, G.B. (1990) Folate-binding proteins.Annu Rev Nutr. 10: 319-35.2. Jones, M.L. & Nixon, P.F. (2002) Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein.J Nutr. 132 (9): 2690-4.
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