|Application ||IHC-P, E|
|Calculated MW||39670 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Synthetic peptide, STPLMSWPWSPSALRLLQRPPEEP, corresponding to the amino acids 1 - 24 of the active cleaved human inhibin alpha chain.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Inhibin alpha chain, INHA|
|Target/Specificity||Rabbit anti-Human inhibin alpha antibody recognizes the human inhibin alpha chain, the product of the INHA gene. The inhibin alpha chain is a 366 amino acid polypeptide with a predicted molecular weight of ~40kDa. It is composed of an N-terminal 18 amino acid signal peptide, two pro-peptide regions of 43 and 171 amino acids respectively and the 134 amino acid inhibin alpha chain. Inhibin alpha dimerizes with with inhibin beta A to form Inhibin A or with the inhibin beta B chain to form inhibin B. The active inhibin alpha chain is derived by cleavage of the inhibin alpha chain from the pro-peptide domains and subsequent dimerization through appropriate disulphide bond formation. Inhibins regulate follicle stimulating hormone secretion from the pituitary gland (Lumpkinet al.1981).Inhibin alpha is expressed in the testis (Bergh and Cajander 1990) and ovary (Cuevaset al.1987,Yamotoet al.1992). Inhibin alpha expression has also been noted in the adrenal glands (McCluggageet al.1998), endomertium (Mylonaset al.2004) and brain (Uccellaet al.200). Inhibin alpha expression has also been noted in a variety of neooplastic tissues including Leydig cell tumors (de Winter et al.1992), brain tumors (Demuraet al.1995), ovarian cancers (Cookeet al.1995) and adrenal carcinomas (Pelkeyet al.1998).Rabbit anti-human inhibin alpha antibody has been utilized successfully for the immunohistochemical localization of inhibin alpha in benign ovarian Brenner tumor (Kuhnet al.2013).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Inhibin alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Kuhn, E. et al. (2013) Ovarian Brenner tumour: A morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium.Eur J Cancer. pii: S0959-8049(13)00776-4.
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