|Calculated MW||99188 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Immunogen||Synthetic peptide corresponding to the amino acids 1242 - 1255 of the native molecule conjugated to Keyhole limpet Haemocyanin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4|
|Target/Specificity||Rabbit anti-Human Androgen Receptor antibody recognizes the human Androgen Receptor (AR) also known as the Dihydrotestosterone receptor or Nuclear receptor subfamily 3 group C member 4. Dihydrotestosterone (DHT) binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. AR homodimers recruit a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, survival, and proliferation. Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development. AR mutations can also cause spinal bulbar muscular atrophy (Kennedy disease) and partial/ complete androgen insensitivity.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Androgen Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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