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Rabbit Anti-Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P10415 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Polyclonal IgG |
| Calculated MW | 26266 Da |
| Purification | Purified IgG prepared by affinity chromatography on Protein G |
|---|---|
| Immunogen | Synthetic peptide corresponding to amino acids 41-54 (GAAPAPGIFSSQPG) of the native molecule conjugated to Keyhole Limpet Haemocyanin. |
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 596 |
| Other Names | Apoptosis regulator Bcl-2, BCL2 |
| Target/Specificity | Rabbit anti-Human Bcl-2 antibody recognizes hman Bcl-2, a 239 amino acid }25 kDa integral outer mitochondrial membrane protein that blocks apoptotic death in a variety of cell systems. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability. It inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1). Bcl-2 is antiproliferative by facilitating G0entry.Constitutive expression of Bcl-2 is thought to be the cause of follicular lymphoma, also known as type II chronic lymphatic leukaemia. Bcl-2 mutations have also been found in Non-Hodgkin Lymphomas. |
| Preservative & Stabilisers | 0.09% Sodium Azide (NaN3) |
| Storage | Store at +4℃ or at -20 ℃. |
| Precautions | Anti-Human Bcl-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Research Areas
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info@abgent.com, and receive a free "I Love Antibodies" mug.
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Cat# ABD10256
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