|Application ||WB, E|
|Calculated MW||206265 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Immunogen||Synthetic peptide corresponding to the amino acids 1 - 11 of the native protein conjugated to Keyhole Limpet Haemocyanin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Ankyrin-1, ANK-1, Ankyrin-R, Erythrocyte ankyrin, ANK1, ANK|
|Target/Specificity||Rabbit anti-Human Erythrocyte Ankyrin antibody recognizes erythroid ankyrin (ankyrin-1), also known as ankyrin R or erythrocyte ankyrin. Ankyrin 1 is a 1881 amino acid ~220kDa cytoplasmic protein forming an attachment for a number of integral membrane proteins and cytoskeletal elements. Ankyrin-1 contains a large number of ankyrin repeats, a death domain and two ZU5 domains (UniProt: P16157).Multiple isoforms of ankyrin-1 are generated by alternative splicing and promptor usage, Rabbit anti-Human Erythrocyte Ankyrin antibody is expected to recognize all erythrocyte isoforms of ankyrin-1 but is not expected to recognize the N-terminally truncated muscle isoforms of ankyrin-1. Additionally Rabbit anti-Human Erythrocyte Ankyrin antibody is likely to cross react with ankyrin-1 from chimpanzee (Pan troglodytes) and lowland gorilla (Gorilla gorilla gorilla). Most ankyrins are composed of 3 structural domains; a N-terminal regulatory domain containing multiple ankyrin repeats, a central spectrin binding domain and a C-terminal regulatory domain. Ankyrin-1 is present in erythrocytes and has also been found in brain and muscle. Mutations in erythrocytic ankyrin-1 are associated with hereditary spherocytosis (Eberet al.1996).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human ANKYRIN-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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