|Application ||WB, E|
|Calculated MW||206265 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Immunogen||Synthetic peptide corresponding to the amino acids 1 - 11 of the native protein conjugated to Keyhole Limpet Haemocyanin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Ankyrin-1, ANK-1, Ankyrin-R, Erythrocyte ankyrin, ANK1, ANK|
|Target/Specificity||Rabbit anti-Human Erythrocyte Ankyrin antibody recognizes erythroid ankyrin (ankyrin-1), also known as ankyrin R or erythrocyte ankyrin. Ankyrin 1 is a 1881 amino acid ~220kDa cytoplasmic protein forming an attachment for a number of integral membrane proteins and cytoskeletal elements. Ankyrin-1 contains a large number of ankyrin repeats, a death domain and two ZU5 domains (UniProt: P16157).Multiple isoforms of ankyrin-1 are generated by alternative splicing and promptor usage, Rabbit anti-Human Erythrocyte Ankyrin antibody is expected to recognize all erythrocyte isoforms of ankyrin-1 but is not expected to recognize the N-terminally truncated muscle isoforms of ankyrin-1. Additionally Rabbit anti-Human Erythrocyte Ankyrin antibody is likely to cross react with ankyrin-1 from chimpanzee (Pan troglodytes) and lowland gorilla (Gorilla gorilla gorilla). Most ankyrins are composed of 3 structural domains; a N-terminal regulatory domain containing multiple ankyrin repeats, a central spectrin binding domain and a C-terminal regulatory domain. Ankyrin-1 is present in erythrocytes and has also been found in brain and muscle. Mutations in erythrocytic ankyrin-1 are associated with hereditary spherocytosis (Eberet al.1996).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human ANKYRIN-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.