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>   home   >   Products   >   Primary Antibodies   >   Anti-Mouse Interleukin-17 Antibody, clone TC11-8H4    

Anti-Mouse Interleukin-17 Antibody, clone TC11-8H4

Rat Anti-Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG1
Clone Names TC11-8H4
Additional Information
Immunogen Recombinant mouse IL-17 expressed in E. coli
Shelf Life 12 months from date of reconstitution.
Target/Specificity Rat anti-mouse Interleukin 17 antibody, clone TC11-8H4 recognizes mouse Interleukin 17, a 32kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family (classified as IL-17A to IL-17F), and signal through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction (Chabaudet al.2000).Rat anti-mouse interleukin-17 antibody has been successfully used for the identification of IL-17 secreting cells in a murine anti-tumor immunity model by ELISPOT analysis (Yuet al.2013)
Preservative & Stabilisers Preservative Free
Storage Store at -20℃ only.
PrecautionsAnti-Mouse Interleukin-17 Antibody, clone TC11-8H4 is for research use only and not for use in diagnostic or therapeutic procedures.
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1. Yu, Y. et al. (2013) Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms.
J Immunol. 190: 1873-81.

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Cat# ABD10320
(40 western blots)
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