|Application ||WB, E|
|Calculated MW||13957 Da|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Cholera enterotoxin subunit B, Cholera enterotoxin B chain, Cholera enterotoxin gamma chain, Choleragenoid, ctxB, toxB|
|Target/Specificity||Rabbit anti-cholera toxin beta antibody recognizes the beta subunit of cholera toxin.The beta subunit of cholera toxin binds to a GM1-ganglioside receptor which is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin alpha subunit into cells. The holotoxin consists of a pentameric ring of beta subunits whose central pore is occupied by the alpha subunit. The alpha subunit contains two chains, A1 and A2, linked by a disulfide bridge. The alpha subunit (and cholera toxin) activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Cholera Toxin beta Antibody (HRP) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Thangawng, A.L. et al. (2010) A hard microflow cytometer using groove-generated sheath flow for multiplexed bead and cell assays.Anal Bioanal Chem. 398: 1871-81. 2. Becker, P.M. et al. (2010) Inhibition of binding of the AB5-type enterotoxins LT-I and cholera toxin to ganglioside GM1 by galactose-rich dietary components.Foodborne Pathog Dis. 7: 225-33.
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