|Calculated MW||71864 Da|
|Immunogen||Choline acetyltransferase purified from rat brain|
|Shelf Life||18 months from date of despatch.|
|Other Names||Choline O-acetyltransferase, CHOACTase, ChAT, Choline acetylase, 220.127.116.11, Chat|
|Target/Specificity||ABD10399 is specific for choline acetyltransferase and stains cholinergic neurons in the brain and central nervous system.Choline acetyltransferase is an enzyme, present the presynaptic ends of axons, that catalyzes the transfer of the acetyl group of acetyl CoA to choline, forming the neurotransmitter acetylcholine.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Rat Choline Acetyltransferase Antibody, clone 1E6 (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hagg, T. et al. (1988) Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damageExp Neurol. 101: 303 - 312 2. Dietz, G. W., Jr. & Salvaterra, P. M. (1980) Purification and peptide mapping of rat brain choline acetyltransferase J. Biol. Chem. 255: 10612 - 10617. 3. Crawford, G. D., et al. (1982) Interaction of monoclonal antibodies with mammalian choline acetyltransferase.Proc Natl Acad Sci U S A. 79: 7031 - 7035. 4. Matthews, D. A. et al. (1987) An immunocytochemical study of choline acetyltransferase-containing neurons and axon terminals in normal and partially deafferented hippocampal formationBrain Res. 402: 30 - 43 5. Hagg, T. et al. (1989) Nerve growth factor (NGF) reverses axotomy-induced decreases in choline acetyltransferase, NGF receptor and size of medial septum cholinergic neuronsBrain Res. 505: 29 - 38. 6. Lindh, B., et al. (1986) Immunohistochemical demonstration of choline acetyltransferase-immunoreactive preganglionic nerve fibers in guinea pig autonomic ganglia. Proc Natl Acad Sci U S A.83: 5316 - 5320. 7. Hagg, T. et al. (1992) Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNSNeuron 8: 145-158.
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