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Anti-Human C1q Antibody (HRP)

Sheep Anti-Human Polyclonal Antibody

  • E - Anti-Human C1q Antibody (HRP) ABD10431
    Published customer image: Levels of factors of the CP and LP; plotted values are nonlog for ease of comprehension. (A) Plasma levels of C1q, (B) MBL oligomer, (C) C-reactive protein, and (D) immunocomplex-CIC-C1q in dengue-infected individuals at different stages of infection (acute and convalescent) and in healthy subjects. All complement proteins were measured by ELISA. Values shown are means and standard deviations. The p-values of two-tailed t-tests on the log-transformed data are indicated above each analysis.From: Nascimento EJM, Silva AM, Cordeiro MT, Brito CA, Gil LHVG, et al. Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity. PLoS ONE 4: e6782.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02746
Other Accession P02747, P02745
Reactivity Human
Host Sheep
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 26722 Da
Additional Information
Purification Antisera to human C1q were raised by repeated immunisation of sheep with highly purified antigen. Purified IgG was prepared from whole serum by protein G affinity chromatography.
Immunogen Human C1q.
Shelf Life 18 months from date of despatch.
Gene ID 713
Other Names Complement C1q subcomponent subunit B, C1QB
Target/Specificity Sheep anti-Human C1q antibody recognizes human C1q, a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis (Troedsonet al.2013).Sheep anti-human C1q antibody may cross react with C1q in other species.
Preservative & Stabilisers 0.01% Thiomersal ; HRP Stabiliser
Storage Store at +4℃. DO NOT FREEZE.
PrecautionsAnti-Human C1q Antibody (HRP) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Nascimento, E.J. et al. (2009) Alternative complement pathway deregulation is correlated with dengue severity.
PLoS One. 4:e6782 2. Lewis, M.J. et al. (2007) The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies.
Mol Immunol. 45: 818-27. 3. Jacobs, B.C. et al. (2003) Immunoglobulins inhibit pathophysiological effects of anti-GQ1b-positive sera at motor nerve terminals through inhibition of antibody binding.
Brain. 126: 2220-34. 4. Arduin, E. et al. (2015) Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a.
Mol Immunol. 63 (2): 456-63. 5. Kao Daniela et al. (2015) A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors
Cell Reports. 6 Dec [Epub ahead of print]

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Cat# ABD10431
(40 western blots)
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