|Calculated MW||188305 Da|
|Purification||Ig fraction prepared by ion exchange chromatography|
|Immunogen||Human C5, purified from plasma.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5 beta chain, Complement C5 alpha chain, C5a anaphylatoxin, Complement C5 alpha' chain, C5, CPAMD4|
|Target/Specificity||Sheep anti-human C5 polyclonal antibody recognizes complement component 5 (C5), a member of the complement system. The complement system consists of a tightly regulated network of proteins. Its activation leads to a sequential cascade of enzymatic reactions, resulting in opsonisation of the pathogens and their removal by phagocytes, as well as cell lysis. Three pathways have been described, the antibody-dependent pathway (classical pathway), the alternative pathway and the lectin activation pathway (Ehrnthaller et al. 2011,Nesargikar et al. 2012). The complement system plays a critical role in both innate and adaptive immune responses. It is also involved in tissue regeneration, tumor growth and some human pathologies (Sarma et al. 2011).Complement component 5 is the initiator of the effector terminal phase of the complement system. C5 convertase cleaves C5 into C5a, a potent anaphylatoxin, and C5b, ultimately resulting in the formation of the multimeric membrane attack complex (MAC) together with the other components of the terminal pathway (C5b-C9) (Noris et al. 2013).Sheep anti-human polyclonal antibody gives a single arc when tested by immunoelectrophoresis (IEP) against human plasma. The identity has been confirmed by double diffusion against fresh human plasma and a known anti-human C5.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.1% EACA; 0.01% Benzamidine; 1mM EDTA|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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