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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Desmoplakin 1/2 Antibody, clone DP-2.15    

Anti-Desmoplakin 1/2 Antibody, clone DP-2.15

Mouse Anti-Human Monoclonal Antibody

  • IF - Anti-Desmoplakin 1/2 Antibody, clone DP-2.15  ABD10458
    Published customer image:Mouse anti Human desmoplakin 1/2 antibody, clone DP-2.15 used for the detection of desmoplakin expressing human cardiomyocytes by immunofluorescence.Image caption:Cardiac matrix coatings increase hESC derived cardiomyocyte maturation compared to the standard gelatin substrate. hESC-derived cardiomyocytes were cultured on gelatin (a and c) or cardiac matrix (b and d) and stained for Titin M8 (red), desmoplakin (green), or nuclei (blue). Cell cluster area (e), number of nuclei per cluster (f), and average desmoplakin positive area (g) were measured and compared between the two coatings. Cardiomyocytes had an increased cluster area and number of nuclei at both day 35 and 112. At day 112, the average desmoplakin immunoreactive area was significantly greater on the cardiac matrix, with localization observed at the lateral ends of the cardiomyocytes (arrows), indicating the formation of desmosomes and a more mature phenotype. **p
  • IHC-P - Anti-Desmoplakin 1/2 Antibody, clone DP-2.15  ABD10458
    Published customer image:Mouse anti Desmoplakin 1/2 antibody used for the detection of desmoplakin expressing cells in porcine meninges by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.Image caption:Immunohistochemical analysis of the porcine meninges. The meninges composed of the dura mater (A–G), the arachnoid mater (H–I) and the pia mater (J–M) in formalin fixed tissue. The porcine spinal cord was cryosectioned and the porcine dura mater (N–O) was stained. The tissue sections were labeled for: (A) von Willebrand factor, (B and K) fibronectin, (C and J) vimentin, (D) laminin, (E) collagen I, (F and M) collagen II, (G, H, and L) integrin 1ß, (I) Desmoplakin, (N) collagen III, (O) E-cadherin. Images were captured at ×200 magnification.From: Papageorgiou I, Marsh R, Tipper JL, Hall RM, Fisher J, Ingham E. Interaction of micron and nano-sized particles with cells of the dura mater.J Biomed Mater Res B Appl Biomater. 2014 Oct;102(7):1496-505.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15924
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names DP-2.15
Calculated MW 331774 Da
Additional Information
Other Species B,C,M,Rat
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Native bovine desmoplakin 1 and 2 purified from bovine snout desmosomes.
Shelf Life 18 months from date of despatch.
Gene ID 1832
Other Names Desmoplakin, DP, 250/210 kDa paraneoplastic pemphigus antigen, DSP
Target/Specificity Mouse anti-Desmoplakin 1/2 antibody, clone DP-2.15 recognizes both desmoplakin 1 and 2 from stratified epithelia, simple epithelia including glands, urothelium, thymic reticular epithelium, hepatocytes, intercalated disks of myocardium and arachnoid cells of meninges. Mouse anti-Desmoplakin 1/2 antibody, clone DP-2.15 can be used for the detection of primary and metastatic carcinomas.Mouse anti-Desmoplakin 1/2 antibody, clone DP-2.15 recognizes the N terminus of the rod domain of desmoplakin (Bornslaegeret al.1996).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Desmoplakin 1/2 Antibody, clone DP-2.15 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Cowin, P. et al. (1985) The complement of desmosomal plaque proteins in different cell types.
J. Cell Biol. 101:1442-1454. 2. Jheon, A.H. et al. (2011) PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.
J Cell Sci. 124: 745-54. 3. Bornslaeger, E.A. et al. (1996) Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly.
J. Cell. Biol. 134: 985-1001. 4. Park, D.S. et al. (2015) Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
J Clin Invest. 125 (1): 403-12. 5. DeQuach JA et al. (2010) Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture.
PLoS One. 5 (9): e13039. 6. Basheer, W.A. et al. (2015) Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.
J Mol Cell Cardiol. 88: 1-13.

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Cat# ABD10458
(40 western blots)
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