|Application ||WB, IHC-F, IF|
|Calculated MW||331774 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Native bovine desmoplakin 1 and 2 purified from bovine snout desmosomes.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Desmoplakin, DP, 250/210 kDa paraneoplastic pemphigus antigen, DSP|
|Target/Specificity||Mouse anti-Desmoplakin 1/2 antibody, clone DP-2.15 recognizes both desmoplakin 1 and 2 from stratified epithelia, simple epithelia including glands, urothelium, thymic reticular epithelium, hepatocytes, intercalated disks of myocardium and arachnoid cells of meninges. Mouse anti-Desmoplakin 1/2 antibody, clone DP-2.15 can be used for the detection of primary and metastatic carcinomas.Mouse anti-Desmoplakin 1/2 antibody, clone DP-2.15 recognizes the N terminus of the rod domain of desmoplakin (Bornslaegeret al.1996).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Desmoplakin 1/2 Antibody, clone DP-2.15 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Cowin, P. et al. (1985) The complement of desmosomal plaque proteins in different cell types.J. Cell Biol. 101:1442-1454. 2. Jheon, A.H. et al. (2011) PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.J Cell Sci. 124: 745-54. 3. Bornslaeger, E.A. et al. (1996) Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly.J. Cell. Biol. 134: 985-1001. 4. Park, D.S. et al. (2015) Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.J Clin Invest. 125 (1): 403-12. 5. DeQuach JA et al. (2010) Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture.PLoS One. 5 (9): e13039. 6. Basheer, W.A. et al. (2015) Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.J Mol Cell Cardiol. 88: 1-13.
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