|Application ||IHC-F, IRMA|
|Other Accession||P05305, P14138|
|Calculated MW||19960 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Synthetic peptide corresponding to the c-terminal region of human endothelin (C,H,L,D,I,I,W), conjugated to BSA.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Endothelin-2, ET-2, Preproendothelin-2, PPET2, EDN2|
|Target/Specificity||Reacts with the C terminal of endothelins 1, 2 and 3. 3G10 does not react with the endothelin precursor molecule, big endothelin. The endothelins are potent vasoconstrictors and critical components in the progression of pulmonary arterial hypertension a devastating and rapidly progressive condition that leads to right ventricular strain and dysfunction.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Endothelin Antibody, clone 3G10 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Yao, J. et al. (2001) Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion andactivation in rat mesangial cells.Am J Physiol Renal Physiol. 280: F628-635.
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