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>   home   >   Products   >   Primary Antibodies   >   Anti-Epstein-Barr Virus Nuclear Antigen Antibody, clone 0211 (6F9/60)    

Anti-Epstein-Barr Virus Nuclear Antigen Antibody, clone 0211 (6F9/60)

Mouse Anti-Viral Monoclonal Antibody

  • IHC - Anti-Epstein-Barr Virus Nuclear Antigen Antibody, clone 0211 (6F9/60)  ABD10480
    Published customer image:Mouse anti Epstein-Barr virus nuclear antigen-1 antibody, clone 0211 used for the detection of EBNA-1 positive cells in cancer tissues by immunohistochemistry on formalin fixed, paraffin embedded tissue sections following antigen retrieval in citrate buffer pH6.0.Image caption:Immunohistochemical detection of EBNA-1 in breast tissue specimens. A. Tumor cells (infiltrating ductal carcinoma) showing intense granular nuclear positivity for EBNA-1 antibody. B. Benign breast tissue negative for EBNA-1; C. Positive control (nasopharyngeal carcinoma tumor cells showing nuclear positivity for EBNA-1) slide; D. Negative control (no signal is seen in infiltrating ductal carcinoma cells without application of primary antibody). All photographs and in 400x original magnification.From: Joshi D, Quadri M, Gangane N, Joshi R, Gangane N Association of Epstein Barr Virus Infection (EBV) with Breast Cancer in Rural Indian Women. PLoS ONE 4: e8180.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Virus
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 0211 (6F9/60)
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Epstein-Barr virus.
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-Epstein-Barr Virus Nuclear Antigen antibody, clone 0211 recognizes Epstein-Barr Virus Nuclear Antigen, also known as EBNA-1. EBNA-1 is a 641 amino acid ~75 kDa viral protein required to maintain the EBV genomes in proliferating cells. It fulfils this role by binding to recognition sites in the FR and DS elements of the latent origin of DNA replication (oriP) within the episome. This promotes DNA replication and is involved with the partitioning of the episome during cell division and the activation of other viral latency genes.EBNA1 is able to avoid detection by cytotoxic T-lymphocytes which enables the persistence of latently infected cells that express EBNA1 in the absence of other EBV antigens.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Epstein-Barr Virus Nuclear Antigen Antibody, clone 0211 (6F9/60) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Joshi, al. (2009) Association of Epstein Barr Virus Infection (EBV) with Breast Cancer in Rural Indian Women.
PLoS ONE. 4: 1-8. 2. Tempera, I. et al. (2015) Identification of MEF2B, EBF1, and IL6R as direct gene targets of EBNA1 critical for EBV-infected B-lymphocyte survival.
J Virol. pii: JVI.02318-15. 3. Hippocrate A et al. (2011) Possible role of EBV in breast cancer and other unusually EBV-associated cancers.
Cancer Lett. 305 (2): 144-9.

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Cat# ABD10480
(40 western blots)
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