Anti-Epstein-Barr Virus Nuclear Antigen Antibody, clone 0211 (6F9/60)
Mouse Anti-Viral Monoclonal Antibody
|Application ||WB, IHC-P, IP|
|Clone Names||0211 (6F9/60)|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti-Epstein-Barr Virus Nuclear Antigen antibody, clone 0211 recognizes Epstein-Barr Virus Nuclear Antigen, also known as EBNA-1. EBNA-1 is a 641 amino acid ~75 kDa viral protein required to maintain the EBV genomes in proliferating cells. It fulfils this role by binding to recognition sites in the FR and DS elements of the latent origin of DNA replication (oriP) within the episome. This promotes DNA replication and is involved with the partitioning of the episome during cell division and the activation of other viral latency genes.EBNA1 is able to avoid detection by cytotoxic T-lymphocytes which enables the persistence of latently infected cells that express EBNA1 in the absence of other EBV antigens.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Epstein-Barr Virus Nuclear Antigen Antibody, clone 0211 (6F9/60) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Joshi, D.et al. (2009) Association of Epstein Barr Virus Infection (EBV) with Breast Cancer in Rural Indian Women.PLoS ONE. 4: 1-8. 2. Tempera, I. et al. (2015) Identification of MEF2B, EBF1, and IL6R as direct gene targets of EBNA1 critical for EBV-infected B-lymphocyte survival.J Virol. pii: JVI.02318-15. 3. Hippocrate A et al. (2011) Possible role of EBV in breast cancer and other unusually EBV-associated cancers.Cancer Lett. 305 (2): 144-9.
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