|Application ||WB, IHC-F, IP|
|Calculated MW||101579 Da|
|Purification||Purified Ig prepared by affinity chromatography|
|Immunogen||Synthetic peptide corresponding to the C terminal region of the native molecule conjugated to Bovine Serum Albumin.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1, Gria1, Glur1|
|Target/Specificity||ABD10539 recognises the glutamate receptor 1 (also known as AMPA) which acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.This antibody linked to immobilized Protein A immunoprecipitates detergent-solubilized receptor from brain or transfected cells.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat Glutamate Receptor 1 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Petralia, R. S. & Wenthold, R. J. (1992) Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brainJ Comp Neurol 318: 329 - 354 2. Wenthold, R. J. et al. (1992) Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brainJ Biol Chem 267: 501 - 507
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