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>   home   >   Products   >   Primary Antibodies   >   Anti-Human Histone H1 Antibody, clone AE-4    

Anti-Human Histone H1 Antibody, clone AE-4

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names AE-4
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Nuclei from myeloid leukamia biopsy cells.
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-Human Histone H1 antibody, clone AE-4 recognizes histone H1.The histone proteins serve as a structural scaffold for the organization of nuclear DNA into chromatin. In eukaryotic cells there are 4 core histone proteins, H2A, H2B, H3 and H4 that assemble to form an octamer round which the DNA is wrapped in a sequence dependant manner. The resulting complex is known as a nucleosome and is the basic subunit of chromatin. Histone H1 acts as a linker and binds to each nucleosome, and by self affinity, links these nucleosomes together resulting in the 30 nm chromatin fiber.In blots of rat brain homogenate a duplet is observed at 27-29 kDa consistent with Histone H1. Speckled staining is observed in the nucleus of normal and malignant cells.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Histone H1 Antibody, clone AE-4 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Swindle, C. S. & Engler, J. A. (1998) Association of the human papillomavirus type 11 E1 protein with histone H1.
J. Virol. 72(3): 1994-2001. 2. Hole, P.S. et al. (2010) Ras-induced reactive oxygen species promote growth factor-independentproliferation in human CD34+ hematopoietic progenitor cells.
Blood. 115:1238-46.2. Wang, X. et al. (2004) Histone H1-like protein participates in endothelial cell-specific activation of the von Willebrand factor promoter.
Blood. 104(6): 1725-1732.

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Cat# ABD10573
(40 western blots)
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