|Application ||WB, IHC-F, IF, E, IP|
|Calculated MW||343905 Da|
|Immunogen||Purified Human Merosin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Laminin subunit alpha-2, Laminin M chain, Laminin-12 subunit alpha, Laminin-2 subunit alpha, Laminin-4 subunit alpha, Merosin heavy chain, LAMA2, LAMM|
|Target/Specificity||ABD10628 reacts with the 80 kD fragment of the M-chain of human Laminin alpha2, originally known as Merosin. Laminins are trimeric basement glycoproteins consisting of three non-identical multi-domain chains (alpha, beta and gamma) each encoded by a distinct gene. The alpha2 chain is a subunit of Laminin-2 and Laminin-4, which are widely expressed in the basement membrane of skeletal muscle and peripheral nerves. Laminins are thought to mediate cell attachment, migration, proliferation and differentiation with other extracellular matrix components.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Laminin alpha 2 Antibody, clone 5H2 (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Tan, E. et al. (1997) Late onset muscular dystrophy with cerebral white matter changes due to partial merosin deficiency. Neuromuscul. Disord. 7: 85-89. 1. Engvall, E. et al. (1990) Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits. Cell Regul. 1: 731-740. 1. Sewry, C.A. et al. (1995) Expression of laminin subunits in human fetal skeletal muscle. Histochem. J. 27: 497-504.
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