|Application ||IHC-P, E|
|Clone Names||8003 (99/12)|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Purified human pepsinogen 1.|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti-Human pepsinogen 1 antibody, clone 8003 recognizes human Pepsinogen I, a zymogen or proenzyme secreted by chief cells in the stomach. It is cleaved to form pepsin both in an autocatalytic fashion and by pepsin itself. In humans there are two related forms of pepsin, Pepsinogen I (also known as pepsinogen A), and Pepsinogen II (also known as Pepsinogen B or progastricsin).Mouse anti-Human pepsinogen 1 antibody, clone 8003 has an affinity of 4 x 1010 l/mol human Pepsinogen I.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Pepsinogen I Antibody, clone 8003 (99/12) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Ueyama, H. et al. (2010) Gastric adenocarcinoma of fundic gland type (chief cell predominant type): proposal for a new entity of gastric adenocarcinoma.Am J Surg Pathol. 34: 609-19. 2. Genta, R.M. & Pusztaszeri, M. (2006) The gastric mucosa in gastric cancer patients in a low-incidence area.Eur J Gastroenterol Hepatol. 18 (10): 1085-93. 3. Fujita Y et al. (2015) Incidence of lymphatic involvement in differentiated-type intramucosal gastric cancers as examined by endoscopic resection.Gastric Cancer. Feb 1. [Epub ahead of print] 4. Hidaka, Y. et al. (2013) Alteration in the Wnt/ß-catenin signaling pathway in gastric neoplasias of fundic gland (chief cell predominant) typeHum Pathol. 44: 2438-48. 5. Sakamoto, H. et al. (2011) Cell lineage dynamics in the process leading to intestinal metaplasia.J Gastroenterol. 46: 620-8.
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