|Application ||WB, IHC-P, IHC-F, IF, FC, IP|
|Calculated MW||123968 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Human skin fibroblast cell membrane extracts.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Platelet-derived growth factor receptor beta, PDGF-R-beta, PDGFR-beta, 188.8.131.52, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, PDGFR-1, CD140b, PDGFRB, PDGFR, PDGFR1|
|Target/Specificity||Mouse anti-Human CD140b antibody, clone PR7212 recognizes the extracellular domain of the human PDGF receptor beta subunit. This was confirmed in binding studies using several different cell lines and by its ability to immunoprecipitate PDGF receptor beta complexed with 125I-PDGF-BB. Mouse anti-Human CD140b antibody, clone PR7212 does not recognize PDGF receptor alpha. PDGF receptor beta is a member of the class III receptor tyrosine kinase family that also includes M-CSF receptor, SCF receptor and Flt-3. Binding of PDGF-BB induces receptor homodimerization or heterodimerization with PDGF receptor alpha.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD140b Antibody, clone PR7212 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hart, C.E. et al. (1987) Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody.J Biol Chem. 262: 10780-5. 2. Hart, C.E. et al. (1988) Two classes of PDGF receptor recognize different isoforms of PDGF.Science. 240: 1529-31. 3. Franklin, W.A. et al. (1990) In situ distribution of the beta-subunit of platelet-derived growth factor receptor in nonneoplastic tissue and in soft tissue tumors.Cancer Res. 50: 6344-8. 4. Seifert, R.A. et al. (1989) Two different subunits associate to create isoform-specific platelet-derived growth factor receptors.J Biol Chem. 264: 8771-8. 5. Krane, J.F. et al. (1991) Increased dermal expression of platelet-derived growth factor receptors in growth-activated skin wounds and psoriasis.J Invest Dermatol. 96: 983-6. 6. Palman, C. et al. (1992) Platelet-derived growth factor receptor (beta-subunit) immunoreactivity in soft tissue tumors.Lab Invest. 66: 108-15. 7. Ascoli, V. et al. (1995) Platelet-derived growth factor receptor immunoreactivity in mesothelioma and nonneoplastic mesothelial cells in serous effusions.Acta Cytol. 39: 613-22. 8. Gilbertson, D.G. et al. (2001) Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.J Biol Chem. 276: 27406-14. 9. Wang, J. et al. (1994) Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor B chain expression: an immunohistochemical and in situ hybridization study.Cancer Res. 54: 560-4. 10. Meng, J. et al. (2011) Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice.PLoS One. 6: e17454.
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