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Sheep Anti-Human Polyclonal Antibody
- SPECIFICATION
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- PROTOCOLS
- BACKGROUND
Application 
| IHC-F, E |
|---|---|
| Primary Accession | P07911 |
| Reactivity | Human |
| Host | Sheep |
| Clonality | Polyclonal |
| Isotype | Polyclonal IgG |
| Calculated MW | 69761 Da |
| Other Species | M |
|---|---|
| Purification | IgG fraction prepared by ammonium sulphate fractionation |
| Immunogen | Purified human uromucodulin prepared from urine. |
| Shelf Life | 12 months from date of reconstitution. |
| Gene ID | 7369 |
| Other Names | Uromodulin, Tamm-Horsfall urinary glycoprotein, THP, Uromodulin, secreted form, UMOD |
| Target/Specificity | Sheep anti-Human Tamm Horsfall Glycoprotein antibody is specific for human Tamm Horsfall Protein (THP), also known as uromodulin (Pennicaet al.1987). THP was originally isolated from normal human urine (Tammet al.1952). THP is a 616 amino acid ~85kDa glycoprotein synthesized by the kidney and is the most abundant urinary protein in healthy individuals (Pennicaet al.1987). THP forms the matrix of all urinary casts either alone (hyaline casts) or in association with cellular fragments and filtered proteins (granular casts), casts are indicative of a number of pathological states including glomerulonephritis and vasculitis (Chamberset al.1986).The specificity of sheep anti-human Tamm Horsfall glycoprotein antibody has been confirmed by double diffusion against tamm horsfall glycoprotein and an independent known antibody against THP. |
| Preservative & Stabilisers | 0.09% Sodium Azide (NaN3); 0.1% EACA; 0.01% Benzamidine; 1mM EDTA |
| Storage | Store at +4℃ or at -20 ℃. |
| Precautions | Anti-Human Tamm Horsfall Glycoprotein Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
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References
1. El-Achkar, T.M. et al. (2011) Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism.Am J Physiol Renal Physiol. 300 (4): F999-1007. 2. Hao, S. et al. (2011) Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells.Am J Physiol Renal Physiol. 300: F966-75. 3. Vekaria, R.M. et al. (2006) Immunolocalization of ectonucleotidases along the rat nephron.Am J Physiol Renal Physiol. 290 (2): F550-60. 4. El-Achkar, T.M. et al. (2013) Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury.Am J Physiol Renal Physiol. 304 (8): F1066-75. 5. El-Achkar, T.M. et al. (2008) Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression.Am J Physiol Renal Physiol. 295 (2): F534-44. 6. Nevo, N. et al. (2010) Renal phenotype of the cystinosis mouse model is dependent upon genetic background.Nephrol Dial Transplant. 25: 1059-66. 7. Venables, G. et al. (2011) Ghrelin receptors are expressed by distal tubules of the mouse kidney.Cell Tissue Res. 346: 135-9. 8. Rice, J.C. et al. (2002) Monocyte chemoattractant protein-1 expression correlates with monocyte infiltration in the post-ischemic kidney.Ren Fail. 24: 703-23. 9. Liu, S. et al. (2012) Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury.Autophagy. 8: 826-37. 10. Saito, S. et al. (2011) Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney.Hum Pathol. 42: 848-58. 11. Ferrè, S. et al. (2014) Mutations in PCBD1 cause hypomagnesemia and renal magnesium wasting.J Am Soc Nephrol. 25 (3): 574-86. 12. Maeda-Hori, M. et al. (2014) Plasma CD147 reflects histological features in patients with lupus nephritis.Lupus. 23: 342-52.
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