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Anti-Human TIMP-1 Antibody

Rabbit Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01033
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 23171 Da
Additional Information
Other Species Hs,Rb,B,Ferret,Rat,Sh
Immunogen Human tissue inhibitor of metalloproteinase 1 (TIMP-1).
Shelf Life 18 months from date of despatch.
Gene ID 7076
Other Names Metalloproteinase inhibitor 1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, TIMP-1, TIMP1, CLGI, TIMP
Target/Specificity Rabbit anti-Human TIMP-1 antibody recognizes human Tissue inhibitor of metalloproteinases 1, also known as TIMP-1, Metalloproteinase inhibitor 1, Erythroid-potentiating activity or Fibroblast collagenase inhibitor. TIMP-1 is a 207 amino acid, ~23 kDa secreted glycoprotein containing a 23 amino acid signaling peptide and a single NTR domain. TIMP-1 is a metalloproteinase inhibitor that functions by formation of complexes with target metalloproteinases, binding to their catalytic cofactor leading to irreversible inactivation of the target metalloproteinase. TIMP-1 also functions as a growth factor and activates signalling cascades via CD63 and CD29 (Uniprot: P01033). In humans TIMP-1 also functions to promote growth and differentiation of erythroid progenitors (Gassonet al.1985).Rabbit anti-Human TIMP-1 antibody recognizes both native and denatured TIMP-1, as well as TIMP-1 in and out of enzyme/inhibitor complex. This antibody is not known to be neutralizing.TIMP-1 is expressed by a wide range of cells including microvascular endothelial cells, smooth muscle cells, mesangial cells and some fibroblasts.Rabbit anti-Humn TIMP-1 antibody has been used successfully for the localization of TIMP-1 in a rabbit model of hypertrophic scarring by immunohistochemistry on formalin fixed, paraffin embedded sections (Tarket al.2015).
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human TIMP-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. O'Kane, C.M. et al. (2010) STAT3, p38 MAPK, and NF-{kappa}B Drive Unopposed Monocyte-DependentFibroblast MMP-1 Secretion in Tuberculosis.
Am J Respir Cell Mol Biol. 43: 465-74. 2. Tark, K.C. et al. (2015) Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model.
Eur J Pharmacol. 750C: 151-59.

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Cat# ABD10801
(40 western blots)
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