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>   home   >   Products   >   Primary Antibodies   >   Anti-XPG Antibody, clone 8H7    

Anti-XPG Antibody, clone 8H7

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P28715
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 8H7
Calculated MW 133108 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Recombinant XPG protein produced in baculovirus (185 kD).
Shelf Life 18 months from date of despatch.
Gene ID 2073
Other Names DNA repair protein complementing XP-G cells, 3.1.-.-, DNA excision repair protein ERCC-5, Xeroderma pigmentosum group G-complementing protein, ERCC5, ERCM2, XPG, XPGC
Target/Specificity ABD10833 is specific for the Xeroderma Pigmentosum protein G, a DNA endonuclease involved in the repair of DNA damage. Patients with Xeroderma Pigmentosum have defective ERCC5 genes resulting in very low levels of the endonuclease. Such patients are extremely photosensitive, presenting with erythema and blistering amongst other abnormalities. Due to the severe deficiency in nucleotide excision repair, the skin fibroblasts of patients are exquisitively sensitive to UV leaving them vulnerable to developing skin cancer.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-XPG Antibody, clone 8H7 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Evans, E. et al. (1997) Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein.
EMBO J. 16:625-38. 2. O'Donovan, A. et al. (1994) Isolation of active recombinant XPG protein, a human DNA repair endonuclease.
J Biol Chem. 269:15965-8. 3. Nouspikel, T. et al. (1997) A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: implications for a second XPG function.
Proc Natl Acad Sci USA. 94:3116-21. 4. Caonstaintinou, A. et al. (1999) Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repair.
J Biol Chem.274:5637-48. 5. Araujo, S. J., Nigg, E. A. and Wood, R. D. (2001) Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.
Mol Cell Biol. 21:2281-91.

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Cat# ABD10833
(40 western blots)
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