|Application ||WB, E, Func|
|Calculated MW||16326 Da|
|Purification||Antisera to mouse MCP-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Recombinant mouse MCP-1 (PMP35)|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||C-C motif chemokine 2, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, MCP-1, Platelet-derived growth factor-inducible protein JE, Small-inducible cytokine A2, Ccl2, Je, Mcp1, Scya2|
|Target/Specificity||Rabbit anti-Mouse MCP-1 antibody recognizes mouse monocyte chemotactic protein-1 (MCP-1), also known as CCL2, Small-inducible cytokine A2 or Platelet-derived growth factor-inducible protein JE. Mouse MCP-1 is a 148 amino acid ~16kDa secreted monocyte chemotactic factorThe chemokine MCP-1 is expressed by a range of cells including monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cells and osteoblasts.MCP-1 is thought to play an important role in the inflammatory response of blood monocytes and tissue macrophages.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Mouse MCP-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Tesch GH et al. (1999) Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis.J Clin Invest. 103:73-80 2. Ruan, L. et al. (2009) Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease.Curr Alzheimer Res. 6: 531-40. 3. Carrillo-de Sauvage, M.A. et al. (2012) CCL2-expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo.PLoS One. 7: e30762 4. Ji, Z. et al. (2014) Thiamine Deficiency Promotes T Cell Infiltration in Experimental Autoimmune Encephalomyelitis: The Involvement of CCL2.J Immunol. 193: 2157-67. 5. Zhang, L. et al. (2012) Intra-amniotic administration of E coli lipopolysaccharides causes sustained inflammation of the fetal skin in sheep.Reprod Sci. 19 (11): 1181-9.
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