|Application ||WB, E, Func|
|Calculated MW||16326 Da|
|Purification||Antisera to mouse MCP-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Recombinant mouse MCP-1 (PMP35)|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||C-C motif chemokine 2, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, MCP-1, Platelet-derived growth factor-inducible protein JE, Small-inducible cytokine A2, Ccl2, Je, Mcp1, Scya2|
|Target/Specificity||Rabbit anti-Mouse MCP-1 antibody recognizes mouse monocyte chemotactic protein-1 (MCP-1), also known as CCL2, Small-inducible cytokine A2 or Platelet-derived growth factor-inducible protein JE. Mouse MCP-1 is a 148 amino acid ~16kDa secreted monocyte chemotactic factorThe chemokine MCP-1 is expressed by a range of cells including monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cells and osteoblasts.MCP-1 is thought to play an important role in the inflammatory response of blood monocytes and tissue macrophages.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Mouse MCP-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Tesch GH et al. (1999) Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis.J Clin Invest. 103:73-80 2. Ruan, L. et al. (2009) Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease.Curr Alzheimer Res. 6: 531-40. 3. Carrillo-de Sauvage, M.A. et al. (2012) CCL2-expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo.PLoS One. 7: e30762 4. Ji, Z. et al. (2014) Thiamine Deficiency Promotes T Cell Infiltration in Experimental Autoimmune Encephalomyelitis: The Involvement of CCL2.J Immunol. 193: 2157-67. 5. Zhang, L. et al. (2012) Intra-amniotic administration of E coli lipopolysaccharides causes sustained inflammation of the fetal skin in sheep.Reprod Sci. 19 (11): 1181-9.
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