|Application ||WB, IHC-P|
|Calculated MW||41783 Da|
|Purification||Antiserum to mouse CD193 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide TDEIKTVVESFETTPYEYEWAPPC corresponding to amino acids 5-28 within the N-terminal region of mouse CD193.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Probable C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR3, Macrophage inflammatory protein 1-alpha receptor-like 2, MIP-1 alpha RL2, CD193, Ccr3, Cmkbr1l2, Cmkbr3|
|Target/Specificity||Goat anti-Mouse CD193 antibody recognizes an epitope within the N-terminal (NT) region of mouse CD193, otherwise known as C-C chemokine receptor type 3 or CCR3. CD193 is a 359 amino acid ~42 kDa multi pass transmembrane glycoprotein and member of the G-protein coupled receptor 1 family (UniProt: P51678). CD193 is expressed by basophils, eosinophils, microglia, Th2 cells and dendritic cells. CD193 acts as a receptor for eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13) and RANTES (CCL5), the former being a chemoattractant for eosinophils and basophils. CD193 is involved in leukocyte chemotaxis and, along with CD191 (CCR1), is implicated as a regulator of T cell and dendritic cell interaction during the process of antigen presentation. CD193 is implicated as an activator of eosinophils in allergic lung disease, and is a useful TH2 cell marker in monitoring immune responses. Goat anti-Mouse CD193 antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD193 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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