|Application ||WB, E, Func|
|Calculated MW||60649 Da|
|Purification||Antiserum to mouse M-CSF was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Recombinant mouse M-CSF|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Macrophage colony-stimulating factor 1, CSF-1, MCSF, Processed macrophage colony-stimulating factor 1, Csf1, Csfm|
|Target/Specificity||Goat anti-Mouse M-CSF antibody recognizes mouse M-CSF (Macrophage colony-stimulating factor), a potent lineage restricted haematopoietic growth factor and member of the CSF family of hormone-like glycoproteins, which plays a key role in the regulation of cellular differentiation, proliferation, and the survival of blood monocytes, tissue macrophages and their progenitor cells.Along with sRANKL/CD254/OPGL, M-CSF is essential for osteoclastogenesis, acting through the tyrosine kinase receptor c-fms (colony stimulating factor 1 receptor). A genetic defect in M-CSF is responsible for osteopetrosis in mice (op/op), which are severely deficient in mature macrophages and have a restricted capacity for bone remodelling.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Mouse M-CSF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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