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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   Anti-Mouse Delta-Like Protein 3 Antibody    

Anti-Mouse Delta-Like Protein 3 Antibody

Rabbit Anti-Mouse Polyclonal Antibody

  • WB - Anti-Mouse Delta-Like Protein 3 Antibody  ABD10859
    Mouse brain lysate probed with Rabbit anti Mouse Delta-Like Protein 3 followed by Sheep anti Rabbit IgG:HRP
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NYJ7
Other Accession O88516
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 64618 Da
Additional Information
Purification Antiserum to mouse DLL3 was raised by repeated immunisation of rabbits with protein peptide sequence. Purified IgG was prepared by affinity chromatography on Protein A.
Immunogen Keyhole Limpet Hemocyanin (KLH) conjugated peptide sequence CSPEHGYCEEPDE, corresponding to amino acids 222-234 of mouse DLL3.
Shelf Life 18 months from date of despatch.
Gene ID 10683
Other Names Delta-like protein 3, Drosophila Delta homolog 3, Delta3, DLL3
Target/Specificity Rabbit anti-mouse Delta-like protein 3 recognises mouse Delta-like protein 3 (DLL3), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4.The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL3 is predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis, where it plays a role in somite segmentation, during early development. DLL3 acts as a regulator of Notch 1, as an inhibitor of primary neurogenesis, and studies in mice have linked DLL3-Notch signalling with liver regeneration, and developmental defects. More than 25 mutations in the DLL3 gene are known to be responsible for the autosomal recessive skeletal malformation condition known as spondylocostal dysostosis type 1 (SCDO1), associated with vertebral and rib segmentation defects.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse Delta-Like Protein 3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Bray, S.J. (2006) Notch signalling: a simple pathway becomes complex.
Nat. Rev. Mol. Cell Biol. 7: 678-689

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Cat# ABD10859
(40 western blots)
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