|Application ||IHC-P, IF, IP|
|Other Accession||P24530, P21451|
|Calculated MW||49561 Da|
|Purification||Antiserum to rat ET-B (CT) was raised by repeated immunisation of sheep with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Keyhole limpet haemocyanin (KLH) conjugated C-terminal peptide KANDHGYDNFRSSNN corresponding to amino acids 424 to 437 of rat endothelin B receptor.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Endothelin B receptor, ET-B, ET-BR, Endothelin receptor non-selective type, Ednrb|
|Target/Specificity||ABD10868 specifically recognises an epitope within the C-terminal (CT) region of endothelin B receptor (ET-B), a widely distributed transmembrane protein and member of the G-protein coupled receptor 1 family, which acts as a non-specific receptor for endothelin 1, 2, and 3, and mediates its action by G protein association and activation of a phosphatidylinositol-calcium second messenger system. ABD10868 recognizes epitopes on the cytoplasmic side of the receptor and therefore the cell membrane must be permeable to the antibody. ABD10868 does not block the binding of endothelins. ABD10868 is reported as suitable for use in immunocytochemistry on acetone fixed cells.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Rat Endothelin B Receptor (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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