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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human Lnk (N-Terminal) Antibody    

Anti-Human Lnk (N-Terminal) Antibody

Goat Anti-Human Polyclonal Antibody

  • WB - Anti-Human Lnk (N-Terminal) Antibody  ABD10872
    Western blotting analysis of MOLT4 lysate probed with Goat anti Human LNK
  • WB - Anti-Human Lnk (N-Terminal) Antibody  ABD10872
    Western blotting analysis of HEK293 cells transiently transfected with human Lnk probed with Goat anti Human Lnk Lane A: Mock transfected cells. Lane B: transfected cells
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UQQ2
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 63225 Da
Additional Information
Purification Antisera to LNK (NT) were raised by repeated immunisation of Goat with highly purified antigen.
Immunogen Peptide sequence NGPALQPSSPC from LNK amino-terminus.
Shelf Life 18 months from date of despatch.
Gene ID 10019
Other Names SH2B adapter protein 3, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, Signal transduction protein Lnk, SH2B3, LNK
Target/Specificity Goat anti-Human LNK antibodyrecognizes human SH2B adapter protein 3, also known as Lymphocyte-specific adapter protein Lnk or Lymphocyte adapter protein. LNK is a 575 amino acid SH2B adapteer protein containing a single PH domain and a single SH2 domain. Goat anti-Human LNK antibody binds to an epitope within the N-terminal region of LNK, which regulates cytokine receptor-mediated and growth factor pathways, and plays an essential role in B cell lymphopoiesis.LNK mRNA is preferentially expressed in lymph node and spleen lymphocytes and the expression of LNK in vascular endothelial cells (ECs), increases in response to TNFα. LNK acts as a negative regulator of the pro-inflammatory molecules VCAM-1 and E-selectin induced by TNFα, modulation of P13-kinase and MAPK ERK1/2 activity. LNK is also involved in the negative regulation of Thrombopoietin-mediated cell proliferation and endomitosis in hematopoietic cell lines.
Preservative & Stabilisers 0.02% Sodium Azide; 0.5% Bovine Serum Albumin;
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Lnk (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Fitau, J. et al. (2006) The adaptor molecule LNK negatively regulates TNFα-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and 2 pathways.
J. Biol. Chem. 281: 20148-59 2. Devallière, J. et al. (2012) LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets a-parvin to control cell adhesion and migration.
FASEB J. 26: 2592-606. 3. Gery, S. et al. (2007) Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.
Blood. 110: 3360-4. 4. Gery, S. et al.M (2009) Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F.
J Leukoc Biol. 85: 957-65. 5. Wan, M. et al. (2006) TNF-a Induces Lnk Expression Through PI3K-Dependent Signaling Pathway in Human Umbilical Vein Endothelial Cells
J Surg Res. 136: 53-7. 6. Fitau, J. et al. (2006) The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways.
J Biol Chem. 281: 20148-59. 7. Wan, M. et al. (2007) Eicosapentaenoic acid inhibits TNF-alpha-induced Lnk expression in human umbilical vein endothelial cells: involvement of the PI3K/Akt pathway.
J Nutr Biochem. 18: 17-22. 8. Chatelais, M. et al. (2011) Gene transfer of the adaptor Lnk (SH2B3) prevents porcine endothelial cell activation and apoptosis: implication for xenograft's cytoprotection.
Xenotransplantation. 18: 108-20. 9. Devallière, J. et al. (2012) LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets a-parvin to control cell adhesion and migration.
FASEB J. 26: 2592-606. 10. Fitau, J. et al. (2005) The adaptor protein Lnk modulates endothelial cell activation.
Nephrol Ther. 1: 228-33.1. Tong, W. and Lodish, H.F. (2004) Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.
J. Exp. Med. 200: 569-580.

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Cat# ABD10872
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