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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Human CD271 Antibody    

Anti-Human CD271 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • ICC - Anti-Human CD271 Antibody  ABD10876
    Immunocytochemical staining of A20 mouse B-cell lymphoma cells with Rabbit anti Human CD271
  • WB - Anti-Human CD271 Antibody  ABD10876
    Western blot analysis of 25(A), 50(B) and 100(C) ng purified recombinant human nerve growth factor receptor with Rabbit anti Human CD271
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08138
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 45183 Da
Additional Information
Other Species M
Purification Antisera to CD271 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Recombinant human CD271
Shelf Life 18 months from date of despatch.
Gene ID 4804
Other Names Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16
Target/Specificity Rabbit anti-Human CD271 antibody recognises CD271, a transmembrane protein of ~70-75 kDa, otherwise known as Nerve Growth Factor Receptor (NGFR). It is a pro-apoptotic member of the tumour necrosis factor receptor (TNFR) family and its ligands include NGF, brain derived growth neurotrophic factor (BDNF), NT3 and NT4. CD271 has been shown to interact with tropomyosin-receptor-kinase A (TrkA) forming the high-affinity NGF receptor, while CD271 can signal alone, constituting the low-affinity NGF receptor. When signalling alone, CD271 is involved in apoptosis, neurite outgrowth during development and myelination. Mutations and changes in CD271 expression have been implicated in various pathological diseases including Alzheimer’s Disease, cerebral oedema and retinoblastoma.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD271 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Johnson, D. et al. (1986) Expression and structure of the human NGF receptor.
Cell. 47: 545-554.2. Nykjaer, A. et al. (2005) p75NTR- live or let die.
Curr. Opin. Neurobio. 15: 49-57.3. Schor, N. (2005) The p75 neurotrophin receptor in human development and disease.
Prog. Neurobiol. 77: 201-214.

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Cat# ABD10876
(40 western blots)
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