|Application ||WB, IF|
|Calculated MW||78287 Da|
|Purification||Antisera to Cadherin 13 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to N-terminus of human Cadherin 13.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cadherin-13, Heart cadherin, H-cadherin, P105, Truncated cadherin, T-cad, T-cadherin, CDH13, CDHH|
|Target/Specificity||Rabbit anti-Human cadherin 13 antibody recognizes human Cadherin 13, a ~78 kDa, calcium-dependent, glycoprotein. While Cadherin 13 is a member of the cadherin family, it lacks their conserved cytoplasmic region, being instead anchored to the plasma membrane via glycosylphosphatidylinositol linkage. It is expressed in the heart and CNS with the exception of the cerebellum and spinal cord.Cadherin 13 is classified as a cell-cell adhesion molecule, although it is likely that it’s role is in signalling and not physical adhesion. It is involved in regulating low-density lipoprotein-initiated cell proliferation, keratinocyte proliferation, neural cell growth and may play a role in metabolic regulation. Cadherin 13 protects endothelial cells from oxidative stress-induced apoptosis and may contribute to progression of vascular disorders such as atherosclerosis, restenosis and tumour angiogenesis.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Cadherin 13 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Ivanov, D. (2004) T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells.Cardiovasc Res. 64:132-143.
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