|Application ||WB, IHC-P|
|Calculated MW||97834 Da|
|Purification||Antisera to human TLR5 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a 16 amino acid sequence located near the centre of human TLR5.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3, TLR5, TIL3|
|Target/Specificity||Rabbit anti-Human TLR5 antibody recognizes human Toll-like receptor 5 (TLR5), a 97.6kDa member of the evolutionarily conserved toll-like receptor family (TLRs), expressed at high levels in the liver and detectable in small amounts in most other tissues.TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. TLR5 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and in turn tumour necrosis factor alpha and has been shown to recognize flagellin from both Gram-positive and Gram-negative bacteria.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human TLR5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hayashi, F. et al. (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.Nature. 410: 1099-1103.2. Hawn, T. R. et al. (2003) A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to Legionnaire’s disease. J. Exp. Med. 198: 1563-1572.
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