|Application ||WB, E|
|Calculated MW||26266 Da|
|Purification||Antisera to Bcl-2 were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Peptide with sequence AGRTGYDNREIVMKYC from N-terminal of Bcl-2.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Apoptosis regulator Bcl-2, BCL2|
|Target/Specificity||ABD10889 detects an epitope within the N-terminal (NT) region of Bcl-2, a 25kD integral outer mitochondrial membrane protein that blocks apoptotic death in a variety of cell systems. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability. It inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1). Bcl-2 is antiproliferative by facilitating G0 entry.Constitutive expression of Bcl-2 is thought to be the cause of follicular lymphoma, also known as type II chronic lymphatic leukaemia. Bcl-2 mutations have also been found in Non-Hodgkin Lymphomas.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Bcl-2 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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