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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Bcl-2 (N-Terminal) Antibody    

Anti-Bcl-2 (N-Terminal) Antibody

Goat Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10415
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 26266 Da
Additional Information
Purification Antisera to Bcl-2 were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Peptide with sequence AGRTGYDNREIVMKYC from N-terminal of Bcl-2.
Shelf Life 18 months from date of despatch.
Gene ID 596
Other Names Apoptosis regulator Bcl-2, BCL2
Target/Specificity ABD10889 detects an epitope within the N-terminal (NT) region of Bcl-2, a 25kD integral outer mitochondrial membrane protein that blocks apoptotic death in a variety of cell systems. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability. It inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1). Bcl-2 is antiproliferative by facilitating G0 entry.Constitutive expression of Bcl-2 is thought to be the cause of follicular lymphoma, also known as type II chronic lymphatic leukaemia. Bcl-2 mutations have also been found in Non-Hodgkin Lymphomas.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Bcl-2 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Zinkel, S. et al. (2006) BCL2 family in DNA damage and cell cycle control.
Cell Death Differ. 13: 1351-1359. 2. Aster, J.C. and Logtine, J.A. (2002) Detection of BCL2 rearrangements in follicular lymphoma.
Am. J. Pathol. 160: 759-763.

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Cat# ABD10889
(40 western blots)
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Bulk Size
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