|Application ||WB, E|
|Calculated MW||20472 Da|
|Purification||Antisera to Caveolin 1 were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Peptide sequence C-DELSEKQVYDAH from internal region of Caveolin 1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Caveolin-1, CAV1, CAV|
|Target/Specificity||Goat anti-Human Caveolin 1 antibody recognizes human caveolin-1, a 178 amino acid, ~21kDa membrane associated protein. Caveolin 1 is a scaffolding protein and the main component of the caveolae plasma membranes found in most cell types (Anderson 1998). Two isoforms of caveolin are generated by alternative initiation, they differ in their N-terminal region with caveolin 1β lacking amino acids 1-31 present in caveolin 1α (Vainonenet al.2004). Goat anti-Human caveolin 1 antibody recognizes epitopes within the region between amino acids 34-41 of caveolin 1α and is therefore expected to recognize both isoforms of caveolin 1Caveolin1 is highly expressed in terminally differentiated or quiescent cells, suggesting a possible role for caveolin 1 as a negative regulator of cell proliferation (Galbiatiet al.2001).Caveolin1 has been implicated in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis (Núñez-Wehingeret al.2014).|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Caveolin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hommel, A. et al. (2010) The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis.Mol Cell Biol. 30: 1231-42.1. Williams, T.M. and Lisanti, M.P. (2005) Caveolin-1 in oncogenic transformation, cancer, and metastasis. Am. J. Physiol. Cell. Physiol. 288: 494-506.2. Liu, P. et al. (2002) Multiple functions of caveolin-1. J. Biol. Chem. 277: 41295-41298.
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