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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Anti-Human CDKN2A (C-Terminal) Antibody    

Anti-Human CDKN2A (C-Terminal) Antibody

Goat Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N726
Other Accession P42771
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 13903 Da
Additional Information
Purification Antisera to CDKN2A (isoform 1) were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Peptide with sequence C-HARIDAAEGPSDIPD from C-terminal of CDKN2A.
Shelf Life 18 months from date of despatch.
Gene ID 1029
Other Names Cyclin-dependent kinase inhibitor 2A, isoform 4, p14ARF, p19ARF, CDKN2A {ECO:0000312|EMBL:AAM77919.1}, CDKN2, MLM
Target/Specificity ABD10892 detects an epitope within the C-terminal (CT) region of cyclin-dependent kinase inhibitor 2A (CDKN2A). CDKN2A is a 16kD protein which belongs to the CDKN2 cyclin dependent kinase inhibitor family. It acts as a negative regulator of cell proliferation by interacting strongly with CDK4 and CDK6, thus inhibiting their ability to interact with cyclin D and to phosphorylate the retinoblastoma protein. CDKN2A is an important tumour suppressor and defects in its production results in tumour formation in a wide range of tissues, including cutaneous malignant melanoma and Li-Fraumeni syndrome.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CDKN2A (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Ruas, M. and Peters, G. (1998) The p16INK4a/CDKN2A tumor suppressor and its relatives.
Biochimica et Biophysica Acta 1378. 2. Piepkorn, M. (2000) Melanoma genetics: an update with focus on the CDKN2A (p16)/ARF tumor suppressors.
J. Am. Acad. Dermatol. 42: 705-722.

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Cat# ABD10892
(40 western blots)
Availability: Inquire
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