|Application ||WB, E|
|Calculated MW||48507 Da|
|Purification||Antisera to Urokinase were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Peptide with sequence C-HFLPWIRSHTKEEN from the C-terminal of the Urokinase sequence.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Urokinase-type plasminogen activator, U-plasminogen activator, uPA, 188.8.131.52, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B, PLAU|
|Target/Specificity||ABD10895 detects an epitope within the C-terminal of urokinase, a potent 50kD serine protease which is also known as urokinase plasminogen activator (uPA). uPA cleaves and activates plasminogen to form plasmin and is involved in extracellular cellular matrix degradation and cell signalling. Recent studies have implicated uPA and its receptor in the pathogenesis of inflammation and immunity. A specific polymorphism in the gene encoding uPA may be associated with late-onset Alzheimer’s disease. The levels of uPA, uPAR and its soluble fragments have also been found to be increased in tissues, plasma and other body fluids of cancer patients and to be markers of cancer development and metastasis.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Urokinase (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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