|Application ||WB, E|
|Calculated MW||53895 Da|
|Purification||Antisera to human syntrophin (alpha-1) were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence ASGRRAPRTGLLE corresponding to the N-terminus of syntrophin (alpha-1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Alpha-1-syntrophin, 59 kDa dystrophin-associated protein A1 acidic component 1, Pro-TGF-alpha cytoplasmic domain-interacting protein 1, TACIP1, Syntrophin-1, SNTA1, SNT1|
|Target/Specificity||ABD10899 recognises human syntrophin (alpha-1), a peripheral membrane protein located at the neuromuscular junction. Syntrophin (alpha-1) is expressed at high levels in skeletal muscle and heart, and at lower levels in brain, pancreas, liver, kidney and lung. It is an adaptor protein which is thought to bind and organise the subcellular localisation of membrane proteins such as utrophin and acetylcholine receptor. Syntrophin (alpha-1) also binds phosphatidylinositol 4,5-bisphosphate, it may link various receptors to the dystrophin glycoprotein complex and the actin cytoskeleton.|
|Preservative & Stabilisers||0.02% Sodium Azide; 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Syntrophin alpha 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Ahn, A. et al. (1996) The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. J. Biol. Chem. 271: 2724-2730.
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