|Application ||WB, E|
|Calculated MW||71277 Da|
|Purification||Antisera to human FOXO3A (CT) were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence C-GAKQASSQSWVPG corresponding to the C-terminal region of FOXO3A (NP_001446.1; NP_963853.1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1, FOXO3, FKHRL1, FOXO3A|
|Target/Specificity||ABD10900 recognises human forkhead box O3A (FOXO3A), also known as FKHLR1, a 95kDa member of the forkhead family of transcription factors. FOXO3A is ubiquitously expressed and is an important regulator of apoptosis and the cell cycle. FOXO3A triggers apoptosis by inducing the expression of genes necessary for cell death. In association with RUNX3, FOXO3A is involved in the induction of Bim expression and apoptosis. Translocation t(6;11)(q21;q23) of FOXO3A with the mixed-lineage leukaemia gene is associated with secondary acute leukaemia.|
|Preservative & Stabilisers||0.02% Sodium Azide; 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-FOXO3A (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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1. Dijkers, P. et al. (2002) FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity.J. Cell Biol. 156: 531-542.
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