|Application ||WB, E|
|Calculated MW||29677 Da|
|Purification||Antisera to human MMP7 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence C-QKLYGKRSNSRKK corresponding to the C-terminus of MMP7 (NP_002414.1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Matrilysin, 220.127.116.11, Matrin, Matrix metalloproteinase-7, MMP-7, Pump-1 protease, Uterine metalloproteinase, MMP7, MPSL1, PUMP1|
|Target/Specificity||ABD10901 recognises matrix metalloproteinase 7 (MMP7), a 29.7 kDa member of the MMP family. MMP's are secreted as inactive zymogens which are activated when proteolytically cleaved by extracellular proteinases. They are involved in processes such as embryonic development, reproduction and tissue remodelling where they breakdown the extracellular matrix. This action is also exploited by diseases processes including arthritis and metastasis. MMP7 degrades casein, fibronectin, gelatin types I, III, IV, V, and activates procollagenase. This metalloproteinase has been identified as an activator of the Notch signalling pathway, and is also involved in wound healing and the regulation of defensins in intestinal mucosa.|
|Preservative & Stabilisers||0.02% Sodium Azide; 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human MMP-7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Gaire, M. et al. (1994) Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J. Biol. Chem. 269:2032-2040.
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