|Application ||WB, E|
|Calculated MW||20811 Da|
|Purification||Antisera to human CBX3 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence C-EAFLNSQKAGKEKD corresponding to the C-terminus of CBX (NP_009207.2; NP_057671.2).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Chromobox protein homolog 3, HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein, CBX3|
|Target/Specificity||ABD10903 recognises human chromobox homolog 3 (CBX3), a 20 kDa protein. It binds histone H3 tails methylated at lysine 9, repressing transcription. CBX3 also interacts with lamin B receptor, forming a functional kinetochore through interaction with MIS12 complex proteins. This dual binding may contribute to the association of heterochromatin with the inner nuclear membrane.|
|Preservative & Stabilisers||0.02% Sodium Azide; 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-CBX3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Ye, Q. et al. (1996) Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. J. Biol. Chem. 271:14653-14656.
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