|Application ||WB, E|
|Calculated MW||50396 Da|
|Purification||Antisera to human LXR Alpha/Beta were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence CRLQDKKLPPLLSEI corresponding to the internal region of LXR Alpha/Beta (NP_005684; NP_009052).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Oxysterols receptor LXR-alpha, Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3, NR1H3, LXRA|
|Target/Specificity||Goat anti-Human LXR alpha/beta antibody recognizes human Oxysterols receptor LXR-alpha, also known as Liver X receptor alpha or Nuclear receptor subfamily 1 group H member 3. Goat anti-Human LXR alpha/beta antibody detects an epitope corresponding to 429-442aa of human LXR (liver X receptor) alpha which has 100% amino acid sequence homology with 443-456aa of human LXR beta. LXR alpha and beta are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors containing a single nuclear receptor DNA binding domain and each have a molecular weight of ~55kDa.LXR alpha and beta are sterol-responsive with the ability to directly bind several oxysterol metabolites. Many LXR target genes have been identified that implicate these receptors in a variety of physiological processes including cholesterol transport and metabolism (Ulvenet al.2005), glucose metabolism, and inflammation (Steffensenet al.2004).|
|Preservative & Stabilisers||0.02% Sodium Azide; 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-LXR alpha/beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Valledor AF. (2005) The innate immune response under the control of the LXR pathway. Immunobiology. 210: 127-132. 2. Michael, L.F. et al. (2005) The pharmacology of LXR. Mini Rev Med Chem. 5: 729-740. 3. Ulven SM, et al. (2005) LXR is crucial in lipid metabolism. Prostaglandins Leukot Essent Fatty Acids. 73: 59-63.
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