|Application ||WB, E|
|Calculated MW||31806 Da|
|Purification||Antisera to human PITP alpha were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence C-VLGIKQGEKHSA corresponding to the C-terminus of PITP alpha (NP_006215).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Phosphatidylinositol transfer protein alpha isoform, PI-TP-alpha, PtdIns transfer protein alpha, PtdInsTP alpha, PITPNA, PITPN|
|Target/Specificity||ABD10908 recognises an epitope within the C-terminal (CT) region of human phosphatidylinositol transfer protein (PITP) alpha, a cytosolic protein with a molecular weight of 32kD. PITP alpha binds and transfers single phosphatidylinositol or phosphatidycholine molecules between membranes. Accumulating evidence has also suggested that PITP proteins play essential functions in choline-phospholipid metabolism, inositol lipid signalling and vesicular membrane traffic. PITP alpha is expressed in a wide range of tissues, and is found in both unicellular and multicellular eukaryotes but not bacteria.|
|Preservative & Stabilisers||0.02% Sodium Azide; 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-PITP alpha (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Tremblay, J.M. et al. (2005) Mechanism of interaction of PITPalpha with membranes: conformational changes in the C-terminus associated with membrane binding.Arch. Biochem. Biophys. 444:112-120. 2. van Tiel, C.M. et al. (2002) The structure of phosphatidylinositol transfer protein alpha reveals sites for phospholipid binding and membrane association with major implications for its function.FEBS Lett. 531:69-73.
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