|Calculated MW||106420 Da|
|Purification||Antisera to PACE4 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: internal domain of human PACE4.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Proprotein convertase subtilisin/kexin type 6, 3.4.21.-, Paired basic amino acid cleaving enzyme 4, Subtilisin-like proprotein convertase 4, SPC4, Subtilisin/kexin-like protease PACE4, PCSK6, PACE4|
|Target/Specificity||ABD10911 detects an epitope within the internal region of human Paired basic amino acid cleaving system 4 (PACE4). PACE4 belongs to the subtilisin-like proprotein convertase family, and is a 100kD calcium dependent serine endoprotease located in the endoplasmic reticulum. It cleaves its substrates at their paired basic amino acid processing sites, converting them into their biologically active products. Several PACE4 substrates have been identified, including transforming growth factor beta-related proteins, proalbumin and von Willebrand factor.In mouse, PACE4 has been shown to increase tumor cell invasiveness, and thus enhance tumor progression. It is thought to have a similar role in humans.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human PACE4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Gensberg, K. et al. (1998) Subtilisin-related serine proteases in the mammalian constitutive secretory pathway. Semin. Cell Dev. Biol. 9: 11-17.2. Khatib, A.M. et al. (2002) Proprotein Convertases in Tumor Progression and Malignancy: Novel Targets in Cancer Therapy. Am. J. Pathol. 160: 1921-1935.
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