|Calculated MW||67660 Da|
|Purification||Antisera to protein kinase C zeta were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: near the N-terminus of human protein kinase C zeta.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Protein kinase C zeta type, 188.8.131.52, nPKC-zeta, PRKCZ, PKC2|
|Target/Specificity||Rabbit anti-human protein kinase c zeta polyclonal antibody recognizes PKCζ a serine/threonine kinase involved in a variety of cell processes including differentiation and proliferation. PKCζ activation is involved in the mitogen-activated protein kinase cascade, transcriptional factor NFkB activation, ribosomal S6-protein kinase signalling, and cell polarity. Work by Ma.et al. in mice has indicated that inhibition of expression of PHGDH by PKCζ acts at a tumor supressor and that loss of PKCζ allows tumor cells to proliferate under glucose deprived conditions leading to poor prognosis.Rabbit anti-human protein kinase c zeta detects an epitope within the N-terminal (NT) region of PKCζ. PKCζ is a member of the atypical PKC subfamily. PKCζ may also be a potential therapeutic target in asthma, and a putative role in other pulmonary diseases, including chronic obstructive pulmonary disease (COPD).|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Protein Kinase C zeta (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hirai, T. and Chida, K. (2003) Protein kinase C zeta (PKC zeta): Activation mechanisms and cellular functions.J. Biochem. 133: 1-7.
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