|Application ||WB, E|
|Calculated MW||50811 Da|
|Purification||Antisera to human RXR alpha were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence CQVNSSLTSPTGRGSM corresponding to the internal region of RXR alpha (NP_002948).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Retinoic acid receptor RXR-alpha, Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha, RXRA, NR2B1|
|Target/Specificity||ABD10913 detects an epitope within the internal region of retinoid X receptor alpha (RXR alpha). RXR alpha is a 54kD member of the steroid/ thyroid receptor superfamily of transcriptional regulators, and is a nuclear receptor that mediates the biological effects of retinoids through its involvement in retinoic acid-mediated gene activation. RXR alpha regulates gene transcription by recruiting coactivators or corepressors to their promoter sequences. RXRs play important roles in multiple signalling pathways, including cell growth, differentiation, homeostasis, metabolism, and development. ABD10913 does not cross-react with either RXR beta or gamma.|
|Preservative & Stabilisers||0.02% Sodium Azide; 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-RXR alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Pestka, A. et al. (2011) Retinoid X receptor a and retinoids are key regulators in apoptosis of trophoblasts of patients with recurrent miscarriages.J Mol Endocrinol. 47 (2): 145-56. 2. Zhang, Z. et al. (2010) Constitutive Activation of the Mitogen Activated Protein Kinase Pathway Impairs Vitamin D Signaling in Human Prostate Epithelial CellsJ Cell Physiol. 224: 433-42.1. Lee, H.Y. et al. (2000) Stress pathway activation induces phosphorylation of retinoid X receptor.J Biol Chem. 275 (41): 32193-9.2. Ghosh, J.C. et al. (2002) Interactions that determine the assembly of a retinoid X receptor/corepressor complex.Proc Natl Acad Sci U S A. 99 (9): 5842-7.3. Konta, T. et al. (2001) Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid.J Biol Chem. 276 (16): 12697-701.
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