|Calculated MW||55711 Da|
|Purification||Antisera to BACE1 (NT) were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a sequence near N-terminus of human BACE1, conjugated to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Beta-secretase 1, 22.214.171.124, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, BACE, KIAA1149|
|Target/Specificity||Rabbit anti-Human BACE1 antibody recognizes human b-site amyloid precursor protein (APP)-cleaving enzyme 1, BACE1, detecting an epitope near the N-terminal region. , BACE1, also known as Beta-secretase 1, Aspartyl protease 2 or Memapsin-2 is a 501 amino acid ~75kDa single pass,type I integral membrane glycoprotein and aspartic protease. BACE1 is a member of the peptidase A1 protein family, and is predominantly expressed in the trans golgi network (Yanet al.2001). BACE1 isexpressed by neurons and astrocytes in the brain (Sunet al.2002).BACE1 catalyzes the cleavage of beta APP at the extracellular, amino-terminal domain leading to the formation of amyloid beta peptide. Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human BACE1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Rossner S, et al. (2005) Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme. J. Neurochem. 92: 226-234.
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