|Calculated MW||109860 Da|
|Purification||Antisera to EphA4 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: internal domain of human EphA4.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Ephrin type-A receptor 4, 188.8.131.52, EPH-like kinase 8, EK8, hEK8, Tyrosine-protein kinase TYRO1, Tyrosine-protein kinase receptor SEK, EPHA4, HEK8, SEK, TYRO1|
|Target/Specificity||ABD10916 detects an epitope within the internal domain of human Ephrin Type A Receptor 4 (EphA4), a 75kD single-pass type I membrane protein which is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA4 is ubiquitously expressed in the body, and is thought to play a role in a number of different developmental pathways, including the corticospinal tract formation, hindbrain pattern formation and regulating the structure of synaptic connections. EphA4 may also act as a locomotor central pattern generator.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human EPHA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Kullander, K. et al. (2001) Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo. Neuron 29: 73-84. 2. Murai, K. K. et al. (2003) Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat. Neurosci. 6: 153-160. 3. Theil, T. et al. (1998) Segmental expression of the EphA4 (Sek-1) receptor tyrosine kinase in the hindbrain is under direct transcriptional control of Krox-20. Development. 125: 443-452.
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