|Application ||WB, E|
|Calculated MW||60188 Da|
|Purification||Antisera to human SLP-76 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence C-ALRNVPFRSEV corresponding to the N-terminus of SLP-76 (NP_005556).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76, LCP2|
|Target/Specificity||ABD10917 recognises the SH2 domain-containing leucocyte protein (SLP-76), a 76kDa tyrosine phosphoprotein, expressed primarily by T lymphocytes and cells of the myeloid lineage.SLP-76 is one of several adaptor proteins assisting with TCR-mediated signal transduction, through GRB2 binding, functioning as a substrate for the protein-tyrosine kinase ZAP-70 and thus playing a crucial role in both T cell ontogeny and activation. Other molecules that associate with SLP-76 include phospholipase C (PLC)–gamma, Vav, Nck and fyn binding protein.|
|Preservative & Stabilisers||0.02% Sodium Azide; 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human SLP-76 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Lasserre, R. et al. (2011) Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.J Cell Biol. 195 (5): 839-53. 2. Lasserre, R. et al. (2010) Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.EMBO J. 29: 2301-14.
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